Dye Disappearance in the Dubin-Johnson Syndrome

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Cholescintigraphy in Dubin-Johnson syndrome.

Hereditary or familial hiperbilirubinemia comprises a group of syndromes (Dubin-Johnson’s, Rotor’s, hepatic storage disease) in which hyperbilirubinemia, predominantly unconjugated or conjugated, occurs as an isolated biochemical abnormality without evidence of either hepatocellular necrosis or cholestasis. We present a patient with Dubin-Johnson syndrome, one of the familial disorders associat...

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Dubin-Johnson syndrome.

A young man presented with recurrent episodes of mild jaundice. Apart from conjugated hyperbilirubinemia, other liver function tests were always normal. Clinical suspicion of Dubin-Johnson syndrome was raised. Liver biopsy showed diffuse deposition of coarse granular dark brown pigment in hepatocytes. Dubin-Johnson syndrome is a benign condition, which results from a hereditary defect in biliar...

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Dubin-Johnson syndrome in a Saudi neonate.

There are many disorders associated with direct hyperbilirubinemia in the neonatal period. These usually need urgent referral to identify treatable diseases. DubinJohnson Syndrome (DJS), which results from impaired hepatic excretory function, is an uncommon cause of neonatal jaundice and is only sporadically reported in neonates. We report here a neonate who presented with direct hyperbilirubin...

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Urinary coproporphyrin isomer distribution in the Dubin-Johnson syndrome.

Urinary coproporphyrinisomer distribution was studied in 13 patients suffering from the Dubin-Johnsonsyndromeand several control groups. In patients with the DubinJohnson syndrome the isomer distribution was quite the reverse to that of normal persons. The urinary isomer distribution was in the normal range in patients with Gilbert’s syndrome, hemolytic jaundice, and fatty liver. In many patien...

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Bile salt transport in the Dubin-Johnson syndrome.

Serum bile salt measurements and intravenous clearance of glycocholate were performed in a woman with Dubin-Johnson syndrome. Fasting conjugated cholate concentration was raised and prolonged intravenous clearance of sodium glycocholate revealed a secondary rise in conjugated cholate concentration after two hours. The intravenous clearance of bromsulphthalein also showed a secondary rise. These...

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ژورنال

عنوان ژورنال: Gastroenterology

سال: 1974

ISSN: 0016-5085

DOI: 10.1016/s0016-5085(74)80093-4